human Bio-engineered Neuronal Organoid (BENO) from W001 wild type line; live
myrTissues are macroscale human tissues to be used in drug discovery and development.
myriamed offers engineered macroscale tissues for advanced screens and target validation. myrTissues are shipped at ambient temperature for immediate use after 24h recovery in appropriate culture medium at 37° C. Each released batch of myrTissue comes with a Certificate of Analysis. Please contact us for details.
myriamed BENOs are highly interconnected neuronal networks in a macroscale tissue format.
They comprise interconnected excitatory and inhibitory neurons with supportive astrocytes and oligodendrocytes.
Giant depolarizing potential (GDP)-like events observed in early BENO cultures mimic early network activity of the fetal brain. A GABA polarity switch and reduced GDPs in >40-day BENO indicate progressive neuronal network maturation. BENOs demonstrate expedited complex network burst development after two months and evidence for long-term potentiation.
Amount/Unit: 1 Tissue / 5 Tissues / 12 Tissues
Shipment Temperature: Room Temperature
Storage at End-user: 37° C
Order related manufacturing: Lead time 7-11 weeks
For more information see also Zafeiriou et al. “Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids.” Nature communications vol. 11,1 3791. 29 Jul. 2020, doi:10.1038/s41467-020-17521-w